Research

We develop novel statistical signal processing tools for analyzing high-dimensional time-series data recorded in various electrophysological modality (EEG/MEG/fMRI) to gather evidence for hypothesis testing in neuroscience of sensory and cognitive processing, demystify whole head spontaneous brain dynamics and discover biomarkers and medical devices utilizing cheap neuro-imaging modality for brain health monitoring.

Highlighted

A dynamic generative model can extract interpretable oscillatory components from multichannel neurophysiological recordings

Proloy Das, Mingjian He, Patrick L Purdon

eLife  ·  15 Aug 2024  ·  doi:10.7554/eLife.97107.3

Switching state-space modeling of neural signal dynamics

Mingjian He, Proloy Das, Gladia Hotan, Patrick L. Purdon

PLOS Computational Biology  ·  28 Aug 2023  ·  doi:10.1371/journal.pcbi.1011395

All

2024

A dynamic generative model can extract interpretable oscillatory components from multichannel neurophysiological recordings

Proloy Das, Mingjian He, Patrick L Purdon

eLife  ·  15 Aug 2024  ·  doi:10.7554/eLife.97107.3

2023

Eelbrain, a Python toolkit for time-continuous analysis with temporal response functions

Christian Brodbeck, Proloy Das, Marlies Gillis, Joshua P Kulasingham, Shohini Bhattasali, Phoebe Gaston, Philip Resnik, Jonathan Z Simon

eLife  ·  29 Nov 2023  ·  doi:10.7554/eLife.85012

Non-Asymptotic Guarantees for Reliable Identification of Granger Causality via the LASSO

Proloy Das, Behtash Babadi

IEEE Transactions on Information Theory  ·  01 Nov 2023  ·  doi:10.1109/TIT.2023.3296336

Switching state-space modeling of neural signal dynamics

Mingjian He, Proloy Das, Gladia Hotan, Patrick L. Purdon

PLOS Computational Biology  ·  28 Aug 2023  ·  doi:10.1371/journal.pcbi.1011395

Changes in Cortical Directional Connectivity during Difficult Listening in Younger and Older Adults

Behrad Soleimani, I.M. Dushyanthi Karunathilake, Proloy Das, Stefanie E. Kuchinsky, Behtash Babadi, Jonathan Z. Simon

Cold Spring Harbor Laboratory  ·  22 May 2023  ·  doi:10.1101/2023.05.19.541500

2022

NLGC: Network localized Granger causality with application to MEG directional functional connectivity analysis

Behrad Soleimani, Proloy Das, I.M. Dushyanthi Karunathilake, Stefanie E. Kuchinsky, Jonathan Z. Simon, Behtash Babadi

NeuroImage  ·  01 Oct 2022  ·  doi:10.1016/j.neuroimage.2022.119496

2021

Eelbrain: A Python toolkit for time-continuous analysis with temporal response functions

Christian Brodbeck, Proloy Das, Marlies Gillis, Joshua P. Kulasingham, Shohini Bhattasali, Phoebe Gaston, Philip Resnik, Jonathan Z. Simon

Cold Spring Harbor Laboratory  ·  03 Aug 2021  ·  doi:10.1101/2021.08.01.454687

2020

Neuro-current response functions: A unified approach to MEG source analysis under the continuous stimuli paradigm

Proloy Das, Christian Brodbeck, Jonathan Z. Simon, Behtash Babadi

NeuroImage  ·  01 May 2020  ·  doi:10.1016/j.neuroimage.2020.116528

Multitaper spectral analysis of neuronal spiking activity driven by latent stationary processes

Proloy Das, Behtash Babadi

Signal Processing  ·  01 May 2020  ·  doi:10.1016/j.sigpro.2019.107429

2018

Cortical Localization of the Auditory Temporal Response Function from MEG via Non-convex Optimization

Proloy Das, Christian Brodbeck, Jonathan Z. Simon, Behtash Babadi

2018 52nd Asilomar Conference on Signals, Systems, and Computers  ·  01 Oct 2018  ·  doi:10.1109/ACSSC.2018.8645204

Dynamic Bayesian Multitaper Spectral Analysis

Proloy Das, Behtash Babadi

IEEE Transactions on Signal Processing  ·  15 Mar 2018  ·  doi:10.1109/TSP.2017.2787146

2017

A Bayesian multitaper method for nonstationary data with application to EEG analysis

P. Das, B. Babadi

2017 IEEE Signal Processing in Medicine and Biology Symposium (SPMB)  ·  01 Dec 2017  ·  doi:10.1109/SPMB.2017.8257055

2016

Introducing Fractional-Order Dynamics to Sigma–Delta Modulators

Proloy Das, Siddhartha Sen

Circuits, Systems, and Signal Processing  ·  02 Feb 2016  ·  doi:10.1007/s00034-015-0241-z