Das Lab National Brain Reserach Centre

Research

We develop of novel statistical signal processing tools for analyzing high-dimensional time-series data recorded in various electrophysological modality (EEG/MEG/fMRI) to gather evidence for hypothesis testing in neuroscience of sensory and cognitive processing, demystify whole head spontaneous brain dynamics and discover biomarkers and medical devices utilizing cheap neuro-imaging modality for brain health monitoring.

Highlighted

A dynamic generative model can extract interpretable oscillatory components from multichannel neurophysiological recordings
A dynamic generative model can extract interpretable oscillatory components from multichannel neurophysiological recordings
Proloy Das, Mingjian He, Patrick L Purdon
eLife  ·  15 Aug 2024  ·  doi:10.7554/eLife.97107.3
Switching state-space modeling of neural signal dynamics
Switching state-space modeling of neural signal dynamics
Mingjian He, Proloy Das, Gladia Hotan, Patrick L. Purdon
PLOS Computational Biology  ·  28 Aug 2023  ·  doi:10.1371/journal.pcbi.1011395

All

2024

A dynamic generative model can extract interpretable oscillatory components from multichannel neurophysiological recordings
A dynamic generative model can extract interpretable oscillatory components from multichannel neurophysiological recordings
Proloy Das, Mingjian He, Patrick L Purdon
eLife  ·  15 Aug 2024  ·  doi:10.7554/eLife.97107.3

2023

Eelbrain, a Python toolkit for time-continuous analysis with temporal response functions
Eelbrain, a Python toolkit for time-continuous analysis with temporal response functions
Christian Brodbeck, Proloy Das, Marlies Gillis, Joshua P Kulasingham, Shohini Bhattasali, Phoebe Gaston, Philip Resnik, Jonathan Z Simon
eLife  ·  29 Nov 2023  ·  doi:10.7554/eLife.85012
Non-Asymptotic Guarantees for Reliable Identification of Granger Causality via the LASSO
Non-Asymptotic Guarantees for Reliable Identification of Granger Causality via the LASSO
Proloy Das, Behtash Babadi
IEEE Transactions on Information Theory  ·  01 Nov 2023  ·  doi:10.1109/TIT.2023.3296336
Switching state-space modeling of neural signal dynamics
Switching state-space modeling of neural signal dynamics
Mingjian He, Proloy Das, Gladia Hotan, Patrick L. Purdon
PLOS Computational Biology  ·  28 Aug 2023  ·  doi:10.1371/journal.pcbi.1011395
Changes in Cortical Directional Connectivity during Difficult Listening in Younger and Older Adults
Changes in Cortical Directional Connectivity during Difficult Listening in Younger and Older Adults
Behrad Soleimani, I.M. Dushyanthi Karunathilake, Proloy Das, Stefanie E. Kuchinsky, Behtash Babadi, Jonathan Z. Simon
Cold Spring Harbor Laboratory  ·  22 May 2023  ·  doi:10.1101/2023.05.19.541500

2022

NLGC: Network localized Granger causality with application to MEG directional functional connectivity analysis
NLGC: Network localized Granger causality with application to MEG directional functional connectivity analysis
Behrad Soleimani, Proloy Das, I.M. Dushyanthi Karunathilake, Stefanie E. Kuchinsky, Jonathan Z. Simon, Behtash Babadi
NeuroImage  ·  01 Oct 2022  ·  doi:10.1016/j.neuroimage.2022.119496

2021

Eelbrain: A Python toolkit for time-continuous analysis with temporal response functions
Eelbrain: A Python toolkit for time-continuous analysis with temporal response functions
Christian Brodbeck, Proloy Das, Marlies Gillis, Joshua P. Kulasingham, Shohini Bhattasali, Phoebe Gaston, Philip Resnik, Jonathan Z. Simon
Cold Spring Harbor Laboratory  ·  03 Aug 2021  ·  doi:10.1101/2021.08.01.454687

2020

Neuro-current response functions: A unified approach to MEG source analysis under the continuous stimuli paradigm
Neuro-current response functions: A unified approach to MEG source analysis under the continuous stimuli paradigm
Proloy Das, Christian Brodbeck, Jonathan Z. Simon, Behtash Babadi
NeuroImage  ·  01 May 2020  ·  doi:10.1016/j.neuroimage.2020.116528
Multitaper spectral analysis of neuronal spiking activity driven by latent stationary processes
Multitaper spectral analysis of neuronal spiking activity driven by latent stationary processes
Proloy Das, Behtash Babadi
Signal Processing  ·  01 May 2020  ·  doi:10.1016/j.sigpro.2019.107429

2018

Cortical Localization of the Auditory Temporal Response Function from MEG via Non-convex Optimization
Cortical Localization of the Auditory Temporal Response Function from MEG via Non-convex Optimization
Proloy Das, Christian Brodbeck, Jonathan Z. Simon, Behtash Babadi
2018 52nd Asilomar Conference on Signals, Systems, and Computers  ·  01 Oct 2018  ·  doi:10.1109/ACSSC.2018.8645204
Dynamic Bayesian Multitaper Spectral Analysis
Dynamic Bayesian Multitaper Spectral Analysis
Proloy Das, Behtash Babadi
IEEE Transactions on Signal Processing  ·  15 Mar 2018  ·  doi:10.1109/TSP.2017.2787146

2017

A Bayesian multitaper method for nonstationary data with application to EEG analysis
A Bayesian multitaper method for nonstationary data with application to EEG analysis
P. Das, B. Babadi
2017 IEEE Signal Processing in Medicine and Biology Symposium (SPMB)  ·  01 Dec 2017  ·  doi:10.1109/SPMB.2017.8257055

2016

Introducing Fractional-Order Dynamics to Sigma Delta Modulators
Introducing Fractional-Order Dynamics to Sigma–Delta Modulators
Proloy Das, Siddhartha Sen
Circuits, Systems, and Signal Processing  ·  02 Feb 2016  ·  doi:10.1007/s00034-015-0241-z